NADPH oxidase: the biochemical basis of CGD
See how a mutation in any of the 5 nicotinamide adenine dinucleotide phosphate (NADPH) oxidase
component genes can lead to life-threatening bacterial and fungal infections.
What is chronic granulomatous disease?
CGD is a rare inherited primary immunodeficiency disorder where the immune system does not work properly. This primary immunodeficiency disorder of phagocytes (neutrophils, monocytes, macrophages, and eosinophils) results in impaired killing of fungi and bacteria, which can lead to severe and recurrent infections.1,2
CGD life expectancy
With the development of preventative therapies and early recognition of infectious complications, 90% of children with CGD now survive into adulthood. This remains, however, largely dependent on several factors, including time of diagnosis, access to care, expertise of caregiver, adherence to therapy, and lifestyle modifications.3,4
Inheriting CGD
CGD can be inherited in 2 ways:
X-linked CGD Carriers
X-linked carriers can experience various symptoms and may be at risk
for serious infections. Carriers may experience CGD-related
lupus-like symptoms including3,7-9
Identifying CGD
Knowing what to look for can aid in the diagnosis of CGD. Suspect CGD in a patient with
CGD lifestyle modifications
Infections can be caused by bacteria and fungi from many places. They live in places like gardens (in mulch), playgrounds (in woodchips), and in lakes and ponds. People with CGD can still enjoy outdoor activities, but they should be cautioned to stay away from these places. Patients with CGD should also avoid the following
Benefits of early diagnosis and treating CGD
Early diagnosis and prophylactic treatment benefits patients with CGD because they have a higher incidence of serious infections* relative to the normal population. Serious infections* can be life-threatening and result in long hospital stays.1,3
To help protect patients with CGD against serious infections,* triple prophylactic therapy consisting of antibiotics, antifungals, and Interferon gamma, such as ACTIMMUNE, is recommended by the10,11
ACTIMMUNE is the only FDA-approved therapy indicated for reducing the frequency and severity of serious infections* associated with CGD.12,13
*Serious infection is defined as a clinical event requiring hospitalization and/or intravenous antibiotics.
INDICATIONS AND USAGE
ACTIMMUNE® (Interferon gamma-1b) is indicated:
Important Safety Information
CONTRAINDICATIONS
WARNINGS AND PRECAUTIONS
USE IN SPECIFIC POPULATIONS
DRUG INTERACTIONS
ADVERSE REACTIONS
Please see Full Prescribing Information for additional safety information.
INDICATIONS AND USAGE
ACTIMMUNE® (Interferon gamma-1b) is indicated:
Important Safety Information
CONTRAINDICATIONS
WARNINGS AND PRECAUTIONS
USE IN SPECIFIC POPULATIONS
DRUG INTERACTIONS
ADVERSE REACTIONS
Please see Full Prescribing Information for additional safety information.